Study had methodological limitations

Methodological Limitations in Determining Astrocytic Gene Expression

Traditionally, astrocytic mRNA and protein expression are studied by in situ hybridization (ISH) and immunohistochemically. This led to the concept that astrocytes lack aralar, a component of the malate-aspartate-shuttle. At least similar aralar mRNA and protein expression in astrocytes and neurons isolated by fluorescence-assisted cell sorting (FACS) reversed this opinion. Demonstration of exp...

Neuroimaging and ADHD: fMRI, PET, DTI findings, and methodological limitations.

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by pervasive and developmentally inappropriate levels of inattention, impulsivity, and hyperactivity. There is no conclusive cause of ADHD although a number of etiologic theories have been advanced. Research across neuroanatomical, neurochemical, and genetic disciplines collectively support a physiolo...

Methodological and Conceptual Limitations in Exercise Addiction Research

The aim of this brief analytical review is to highlight and disentangle research dilemmas in the field of exercise addiction. Research examining exercise addiction is primarily based on self-reports, obtained by questionnaires (incorporating psychometrically validated instruments), and interviews, which provide a range of risk scores rather than diagnosis. Survey methodology indicates that the ...

Possibilities and Limitations in the Biomechanical Analysis of Countermovement Jumps: A Methodological Study

Possibilities and limitations in the biomechanical analysis of countermovement jump performance were examined using force plate data. Four male and 4 female sport students participated in the study. Software designed to test jumping performance was used to evaluate recordings from a force plate and to compute net velocity and net displacement measures for the center of gravity. In parallel, a f...

Birth Outcomes and Natural Gas Development: Methodological Limitations